Science

Des scientifiques révèlent la meilleure façon d’avaler des pilules

Les chercheurs ont découvert que la consommation de pilules en se reposant sur le côté droit était de loin la meilleure, permettant aux pilules d’entrer dans la partie la plus profonde de l’estomac et de se dissoudre 2,3 fois plus rapidement que même une posture debout.

Selon une étude récente de Johns Hopkins, la façon dont vous avalez des pilules peut avoir un impact sur la rapidité avec laquelle votre corps absorbe le médicament.

Vous ne tenez probablement pas compte de votre posture lorsque vous prenez des pilules lorsque vous avez mal à la tête. Cependant, des recherches récentes de Université John Hopkins découvert que votre posture peut avoir un impact significatif sur la rapidité avec laquelle votre corps absorbe le médicament, jusqu’à une heure de plus.

Les conclusions sont basées sur ce que l’on pense être le premier modèle à reproduire la façon dont un médicament se dissout dans l’estomac humain.

“Nous avons été très surpris que la posture ait un effet aussi immense sur le taux de dissolution d’une pilule”, a déclaré l’auteur principal Rajat Mittal, ingénieur de Johns Hopkins et expert en dynamique des fluides. “Je ne me suis jamais demandé si je le faisais bien ou mal, mais maintenant j’y penserai certainement chaque fois que je prendrai une pilule.”

Leurs conclusions ont été récemment publiées dans la revue

Pill Posture

Your posture when taking a pill makes a big difference in how fast your body absorbs the medicine. Credit: Khamar Hopkins/Johns Hopkins University

The majority of pills don’t start working until the stomach passes its contents into the intestine. As a result, the closer a pill falls to the antrum, the quicker it begins to break down and unload its contents into the duodenum, the first part of the small intestine. If you’re aiming a pill for this part of the stomach, your posture is crucial in order to take use of gravity as well as the inherent asymmetry of the stomach.

Four postures were tested by the team. Taking tablets while resting on the right side was by far the most effective, sending pills into the deepest part of the stomach and achieving a dissolution rate that was 2.3 times quicker than even an upright posture. The worst was lying on the left side. The team was astounded to discover that if a tablet dissolves in 10 minutes on the right side, it may take up to 23 minutes in an upright posture and over 100 minutes while laying on the left side.

“For elderly, sedentary or bedridden people, whether they’re turning to left or to the right can have a huge impact,” Mittal said.

Standing upright was a decent second choice, essentially tied in effectiveness with lying straight back.

The team also considered stomachs that aren’t functioning at full strength due to gastroparesis caused by diseases such as diabetes and Parkinson’s Syndrome meant for pill dissolution. Even a small change in the conditions of the stomach can lead to significant differences in the outcome of an oral drug, said lead author Jae Ho “Mike” Lee, a former postdoctoral researcher at Johns Hopkins.

The impact of stomach disease on drug dissolution was similar to that of posture—which underscores how significant a difference posture makes.

“Posture itself has such a huge impact it, it’s equivalent to somebody’s stomach having a very significant dysfunction as far as pill dissolution is concerned,” Mittal said.

Future work will attempt to predict how the changes in the biomechanics of the stomach affect how the body absorbs drugs, how food is processed in the stomach, and the effect of posture and gastroparesis on food digestion.

Reference: “Computational modeling of drug dissolution in the human stomach: Effects of posture and gastroparesis on drug bioavailability” by J. H. Lee, S. Kuhar, J.-H. Seo, P. J. Pasricha and R. Mittal, 9 August 2022, Physics of Fluids.
DOI: 10.1063/5.0096877

The study was funded by the National Science Foundation and the National Institutes of Health.

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